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Why Psilocybin is Favored for the Terminally Ill Among Some Canadians

By April 16, 2024July 9th, 2025Shrooms Online

People grappling with terminal diseases frequently experience intense emotional distress, including depression, anxiety, an existential crisis, and a feeling of lost purpose, which can make their situation even more challenging to manage.

Current treatment options such as counselling or cognitive-behavioural therapy (CBT) can provide relief, but they may not be effective for everyone. Consequently, researchers are investigating new and alternative methods for end-of-life care.

There is growing evidence suggesting that psychedelic therapy could be an effective solution for alleviating existential distress in patients with incurable diseases. A review in the Neuropsychopharmacol Biol Psychiatry journal indicates that psychedelics can help reduce depression and anxiety symptoms, improve quality of life, and lessen fears associated with death in patients with life-threatening conditions.

In order to further investigate the efficacy of psilocybin mushrooms, Canadians often buy shrooms online for research purposes.

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How Psilocybin Affects the Brain

The National Institutes of Health characterizes psychedelics derived from shrooms as powerful substances that can alter cognition. They affect mood and perception by interacting with the brain’s serotonin circuits. 

Let’s examine what various studies have found:

ResearchersFindings
Department of Psychiatry and Behavioral Sciences, University of TexasPsychedelics such as psilocybin interact with serotonin 2A receptors that govern emotions and perception. 
A study from Mental Health NewsPsilocybin, a naturally occurring hallucinogenic compound found in over 200 species of fungi, could potentially reshape the brains of individuals battling depression, potentially leading to a cure.
Researchers from UC San Francisco and Imperial College LondonPsilocybin bolsters connections between different brain regions in depressed individuals, which may aid them in overcoming excessive self-focus and rumination.
A randomized, double-blind trial by John Hopkins University High doses of psilocybin significantly reduced depression, anxiety, and death anxiety, while improving quality of life, sense of life’s meaning, and optimism.
Clinical trial from New York University Between 60% and 80% of participants reported reduced anxiety

Psilocybin therapy has been found to lead to significant reductions in anxiety and depression, which in turn improves distress related to existential crises. Additionally, the study found that these therapeutic effects can be directly linked to the psychedelic experiences triggered by psilocybin.

Research Study

In order to provide supporting evidence for this, researchers from the UCSF Weill Institute for Neurosciences conducted 2 studies. These studies involved a total of 60 participants, all of whom underwent fMRI brain scans.

Methodology

  • Study One. All participants were dealing with depression resistant to current treatments, and were given psilocybin.
  • Study Two. Participants with milder depression were not informed if they were given psilocybin or an antidepressant placebo (escitalopram). All participants received the same psychotherapy.

The researchers took scans before and after treatment to assess the effects.

Results

  • Treatment with psilocybin reduced connections within brain regions linked to depression, such as the default mode, salience, and executive networks. Simultaneously, it increased connections to less integrated areas of the brain.
  • The therapy also reduced emotional avoidance and led to significant improvements in cognitive functioning.

The effects of psilocybin on brain rewiring were sustained for up to three weeks after the second dose. This suggests that psilocybin could serve as a potential alternative treatment for depression by restructuring the brain and mitigating pervasive negative thought patterns associated with the condition. These findings demonstrate that psilocybin works differently than conventional antidepressants.

Psilocybin Therapy – A Promising Treatment Approach

Psilocybin therapy involves the controlled use of psilocybin in a therapeutic setting, usually in conjunction with psychological support. This approach is being increasingly recognized for its potential to treat depression resistant to current treatments, anxiety, and existential distress in terminally ill patients.

A recent survey carried out by researchers from Université Laval’s Faculty of Pharmacy, McGill University, Université de Montréal, and UQAR sought to gauge public opinion on the medicinal use of psilocybin for end-of-life care. According to the study published in Palliative Medicine, nearly 4

One in five Canadians support the application of psilocybin to ease existential distress at the end of life.

Lead researcher Michel Dorval noted that studies have shown that psilocybin, when used in combination with psychotherapy, can provide swift, substantial, and long-lasting relief for individuals grappling with advanced cancer. It’s worth highlighting that psilocybin therapy can provoke a deep sense of comprehension and comfort that may persist for up to six months.

Moreover, the survey indicates an elevated level of support among those with palliative care experience or prior psilocybin use. Dorval suggested that personal encounters with end-of-life distress could contribute to this receptivity towards such unconventional approaches.

Despite the prevailing prejudices against psychedelic drugs, the research signifies a growing endorsement of psilocybin therapy in Canada, particularly within palliative and end-of-life care contexts. The researchers foresee that these results will boost the availability of this groundbreaking therapy.

Additional Benefits of Psilocybin Therapy

1. Treatment for Alcohol Use Disorder

A double-blind, randomized trial involving 93 participants, published in JAMA Psychiatry in August 2022, demonstrated that the blend of psilocybin and psychotherapy significantly reduced the number of heavy drinking days over approximately eight months compared to a placebo group. Moreover, the group treated with psilocybin consumed less alcohol on the days they did drink.

2. Aid in Smoking Cessation

Despite the well-known difficulties in quitting smoking, a preliminary study by researchers at Johns Hopkins University, published in The American Journal of Drug and Alcohol Abuse in January 2017, suggested that psilocybin combined with cognitive behavioural therapy (CBT), helped 10 out of 15 participants to stay smoke-free for a year. A subsequent study proposed that the psychedelic experience could potentially reshape a smoker’s self-concept, thereby fostering long-term abstinence.

3. Therapy for Anorexia

Recent studies indicate that psilocybin may provide benefits for those battling anorexia. A preliminary report published in Biological Psychiatry in May 2022 found significant decreases in symptoms of eating disorders and anxiety in adults with anorexia who underwent psilocybin-assisted psychotherapy.

4. Alleviating End-of-life Anxiety

End of Life

Individuals diagnosed with terminal diseases often grapple with anxiety and depression. However, psilocybin therapy presents a beacon of hope, exhibiting potential to soothe these distressing conditions. Studies have observed substantial reductions in depression and anxiety in patients with critical cancer diagnoses after they engaged in psilocybin therapy.

What to Expect from Psilocybin Therapy?

Psilocybin therapy has the potential to deliver compelling healing results promptly, possibly providing enduring benefits. Each therapy session is personalized, adhering to specific guidelines of the clinic or clinical trial. 

PhaseDescriptionDuration
PriorThe initial sessions are centered around discussing any apprehensions and treatment goals with a facilitator to form a solid bond and safe environment.1 to 6 hours
DuringThe participant ingests a dose of psilocybin in a relaxed setting, lying down with an eye mask on, listening to a chosen playlist, under the guidance of a therapist.5 to 8 hours
SubsequentFollow-up sessions facilitate interpreting the experience with the therapist, thereby aiding in integrating the insights into day-to-day life.Several sessions over varying hours

Tips for Navigating Psilocybin Therapy

  • Investigate clinics where psilocybin is legal, and if required, consider joining a waiting list.
  • Choose a clinic that conducts psilocybin therapy under the supervision of a therapist or a professional guide for a more therapeutic encounter.
  • Interview potential therapists, inquiring about their qualifications, experience, approach towards therapy, and expertise in managing mental health conditions.
  • Be candid about your genuine reasons for seeking therapy, mental health status, medical history, and family mental health background.
  • Take into account therapists who specialize in your specific mental health condition and consider consulting organizations like the Psilocybin Assisted Therapy Association (PATA) for guidance and training.
  • Offer a detailed account of your medical and mental health history, especially if there’s a family history of schizophrenia or psychosis.
  • Discuss your decision to opt for psilocybin therapy with your current mental health provider and inquire if they are open to collaborating with your psilocybin therapy team.
  • Discuss the dosage, protocol, and the need to initiate
  • Especially for those new to psilocybin therapy, it’s recommended to start with lower doses under the guidance of a psilocybin therapist to ensure safety.

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Frequently Asked Questions

Who makes a suitable candidate for psilocybin therapy?

If you are battling depression, anorexia, alcohol addiction, trying to quit smoking, or dealing with a terminal disease, you might want to look into psilocybin therapy. 

Conversely, if you have a personal or family history of schizophrenia or psychosis, hallucinogens like psilocybin could exacerbate your symptoms. Likewise, it’s generally advised against for those with bipolar disorder and borderline personality disorder.

What’s the standard dosage of psilocybin during therapy?

The dosage usually varies, often starting with smaller doses in a therapeutic environment and adjusting based on individual responses. Clinical studies have shown that a single 25-milligram dose of synthetic psilocybin, coupled with psychotherapy, led to decreased depression scores in those with treatment-resistant depression.

Can psilocybin be utilized for treating PTSD?

This is a rapidly growing research area. However, the study of MDMA, a non-traditional psychedelic with stimulant properties used in combination with psychotherapy for PTSD treatment, is more developed. Trials on this psychedelic have reached phase 3 clinical trials, and MDMA is expected to receive approval for treating PTSD this year.

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