Of late, magic mushrooms have piqued curiosity for their potential to assist in managing diverse mental health disorders, particularly depression. A widely embraced approach involves regularly consuming an approximate dose of 25 mg of the active ingredient, procurable from a mushroom dispensary. This dosage seems to show promise in providing relief and may act as a supplement to conventional depression treatments.
A study carried out by a group of scholars indicates that psilocybin, the active compound in magic mushrooms, has demonstrated positive results in depression treatment.
Main Points:
- In as little as eight days, Psilocybin can result in an enhancement of depression symptoms.
- The side effects of Psilocybin are generally well-managed and typically range from mild to moderate.
- A 25mg dose of psilocybin may trigger changes in perception, mood variations, increased creativity, and a sense of unity.
One Dose Does the Trick
A recent study employed a rigorous methodology, using a randomized, multi-blinded design to juxtapose a single dose of psilocybin with an active placebo (niacin). The study evaluated the onset, duration of benefits, and safety of psilocybin over a span of six weeks.
Study Participants
The study targeted individuals aged between 21 and 65 years who met the criteria for Major Depressive Disorder (MDD) as per the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) and were undergoing a depressive episode for at least 60 consecutive days.
Study Procedure
Participants were administered a single 25-mg oral dose of psilocybin or a 100-mg dose of niacin. The role of niacin was to act as an active placebo, inducing an immediate physiological response (flushing) to maintain the blinding aspect.
Both the psilocybin and the niacin placebo were given following a standard “set and setting” procedure. The preparatory sessions, led by two facilitators, lasted between 6 and
The dosing session typically lasted between 7 and 10 hours in a relaxed environment. Participants were prompted to contemplate their experiences four hours after the dosage.
Findings of the Study
Signs of depression reduction became evident just eight days following the administration of psilocybin. This positive effect remained consistent throughout the six-week follow-up. It exhibited higher response and remission rates according to the Montgomery-Asberg Depression Rating Scale (MADRS), relative to other psilocybin studies and Treatment-Resistant Depression.
In comparison to niacin, psilocybin exhibited superior psychosocial functioning. The utilization of psilocybin proved beneficial in several aspects, including reducing overall disease severity, anxiety, self-reported depressive symptoms, and improving the quality of life.
The majority of participants tolerated the compound well, experiencing only minor to moderate side effects, predominantly during the first dose. However, psilocybin treatment showed more frequent and severe side effects than niacin, which is consistent with our existing understanding of its effects.
The researchers emphasized that psychedelics such as psilocybin could trigger side effects that conventional rating scales may not always identify, or could reveal previously undetected psychiatric conditions, even while they effectively treat specific syndromes.
What Does a 25-mg Dose Imply?
A typical psychedelic dose varies between 15 to 25 milligrams of psilocybin (1.5 to 2.5 grams of dried mushrooms). This is the standard dosage for those seeking the full psychedelic effects of magic mushrooms.
This dosage can lead to changes in perception, mood alterations, increased creativity, and a sense of unity with the environment. While slight visual effects may occur, intense hallucinations are rare. It is akin to entering a vibrant dreamworld where reality fuses with a captivating mix of visual and auditory sensations.
The euphoric feelings often manifest as dance, gentle movements, or simply yielding to the psychedelic rhythm. The experience generally lasts for 4 to 8 hours. At this level, visual distortions may become more prominent. Patterns appear to dance and morph, and your surroundings seem to pulsate with energy.
This dosage can be administered in a controlled environment with a positive mindset. It promises an expedition filled with awe and wonder, inspiring you to delve into consciousness with careful excitement.
- Significant enhancements in color perception.
- Visual distortions, including the sensation of objects shifting or “breathing”.
- The phenomenon of synesthesia, such as “seeing sounds” or “hearing colours”.
- A deeper appreciation and understanding of music.
- Periods of intense laughter.
- Alterations in touch sensations.
- The urge for self-reflection.
- Feelings of euphoria.
- Changes in the perception of time.
- An increased heart rate and blood pressure.
What Magic Mushroom Stores Offer
Magic mushroom stores carry a variety of psilocybin-inclusive products. These stores offer a wide selection of items such as dried mushrooms, edibles, capsules, and beverages, among others. Dried mushrooms are particularly sought-after.
Health Canada recognizes over 200 species of magic mushrooms, with Psilocybe cubensis being a commonly sold strain. This strain comes in a number of variants, providing an extensive choice for customers, similar to those found in cannabis dispensaries.
Other Shroom Products Include:
| Edibles | Food products like gummies and chocolates, infused with psilocybin. The dosage is made user-friendly as manufacturers indicate the amount per serving. |
| Capsules | These are tasteless and can be seamlessly integrated into your wellness routine. They contain only small quantities to provide a mild enhancement to your regimen. |
| Beverages | These are akin to edibles, but in liquid form. They are versatile and come in variants like chocolate, coffee, or tea. |
Deciding Your Dosage at Magic Mushroom Dispensaries
Despite magic mushrooms not being a standard treatment for depression, Canada has taken a progressive step. They have approved the testing and medical use of psilocybin, a Schedule I substance under the Controlled Drugs and Substances Act, for specific patients battling severe major depressive disorder. This decision could potentially benefit tens of thousands
Those experiencing anxiety and depression may find clinical trials a useful way to explore alternative treatments.
Commonly Asked Questions
Can I buy psilocybin from a medicinal mushroom dispensary?
Medicinal mushroom dispensaries often carry products like Reishi, Turkey Tail, and Lion’s Mane. For those interested in the realm of mushrooms, online magic mushroom dispensaries can be a good place to start. These dispensaries offer a range of mushroom products, including dried mushrooms and other psychedelic substances.
Is a 25 mg dosage effective for treating depression?
The ideal psilocybin dosage for depression treatment is still being researched. Some studies are focusing on lower dosages, while others are investigating higher amounts of psilocybin. Starting with a microdose and gradually increasing the dosage could be a possible approach.
Can I buy shrooms in Toronto?
Online mushroom vendors make it possible to shop from anywhere in Canada. Regardless of your location, these online platforms ensure delivery straight to your door.
What’s the most budget-friendly product in an online mushroom shop?
Dried mushrooms are often the first choice for customers due to the variety of quantities available. The price can vary depending on whether you need a smaller amount like 1 gram or want to purchase in bulk. While edibles and other products are reasonably priced, they might not be as cost-effective as dried mushrooms.
Can a single dose of shrooms help to alleviate depression?
Some studies suggest that a single dose might be enough to lessen symptoms of depression. However, it’s important to remember that these study participants also engaged in talk therapy alongside the treatment. The combination of psychedelic therapy and therapeutic sessions seems to yield the best results.
About the Author
This article was penned by Charles L. Raison et al.; Jeremy D. Coplan, MD and Dorothy P. Reddy, MD; Albert Garcia-Romeu, Frederick S Barrett, Theresa M Carbonaro, Matthew W Johnson, and Roland R Griffiths; Vince Polito
Richard J. Stevenson, Rebecca Smausz, Joanna Neill, and John Gigg are also part of the team.
Affiliated Organizations:
- The Usona Institute in Fitchburg, Wisconsin
- SUNY Downstate Medical Center located in Brooklyn, New York
- Neurogenesis Clinics in Brooklyn, New York
- The Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine in Baltimore, MD, USA
- Center for Psychedelic and Consciousness Research at Johns Hopkins University School of Medicine in Baltimore, MD, USA
- Department of Neuroscience at Johns Hopkins University School of Medicine in Baltimore, MD, USA
- Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine, located in Baltimore, USA
- Department of Cognitive Science at Macquarie University in Sydney, Australia
- Department of Psychology at Macquarie University in Sydney, Australia
- The Division of Neuroscience and Experimental Psychology within the Faculty of Biology, Medicine and Health at The University of Manchester, UK
- Division of Pharmacy and Optometry in the Faculty of Biology, Medicine and Health at The University of Manchester, UK
- Medical Psychedelics Working Group, partnered with Drug Science, UK
